O-083 Ovarian reserve, Reproductive function and Pregnancy outcomes among Female survivors of childhood Hodgkin lymphoma: results from the DCOG LATER-VEVO Later study

Abstract Study question What is the impact of treatment for Hodgkin lymphoma (HL) on clinical reproductive markers and pregnancy outcomes? Summary answer Impaired ovarian reserve in childhood HL survivors substantiate risk a reduced fertile life span. Pregnancy outcomes seem reassuring at young age. known already Childhood Lymphoma nowadays highly curable with survival rates over 90%. Chemotherapy radiation are associated late adverse effects including function -reserve. design, size, duration This study was embedded within DCOG LATER-VEVO study, nationwide, multicenter, retrospective cohort performed between 2004 2014, which ability 1106 female cancer studied compared to 798 controls (siblings females from general population). Participants/materials, setting, methods The current analysis included all survivors, treated 1963 2002, who provided written informed consent participate study. Data collection consisted questionnaire timed measurements (blood sample transvaginal ultrasound). Serum anti-Mullerian hormone (AMH), FSH, inhibin B, antral follicle count (AFC) self-reported (first) -outcomes were evaluated linear logistic regression models . Main results role chance 84 included, aged 29.6 (IQR 19.8-36.6) 32.7 19.7-49.6) years old time assessment. Median age diagnosis 13.4 6.4-16.4), median since 16.5 8.4;36.6) years. Cyclophosphamide equivalent dose (CED-score) exceeded 6000mg/m2 56 women 14 received pelvic irradiation. All significantly deteriorated (odds-ratio low AMH (<p10) 10.1 [95%CI 4.9;20.6]; AFC 4.6 2.1;9.9]; elevated FSH (>10IU/l) 15.3 5.7;41.1], Inhibin B (<20ng/l) 3.6 [ 95%CI 1.7;7.7], p < 0.001, 45 413 controls). live birth comparable (±80% birth, ±20% miscarriage). However younger first (27.0 vs 29.0 yrs, P = 0.04, 42 389 Time seemed be increased (adjusted odds-ratio >12 months 2.5 [95% CI 1.1;5.6] 0.031). No significant differences weight or gestational observed. Gonadotoxicity specifically present after procarbazine higher CED-score. clear effect Limitations, reasons caution comprised relatively population. Risk premature insufficiency could not assessed considerable number indicated they considered themselves too aim achieve pregnancy. Heterogeneity size issues complicated extent analyses. Wider implications findings appear have an impaired reserve, however seems Additional studies needed assess span potential particular treatments that hypothesized less gonadotoxic. Trial registration NTR2922